Dose-Dependent Impact of Laca-tomtom Mixture on Cerebellar Histomorphology in Wistar Rats
Nwodo N. Francis1, Ogbo F. Ovie2, Nwafor C. Charles3 and Ifedi I. Charles4
1Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medicine, State University Medical and Allied Health Sciences, Igbo-Eno, Nigeria.
2Department of Human Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Delta State University, Ozoro, Nigeria.
3Department of Human Physiology, Faculty of Basic Medical Sciences, ESUT College of Medicine, Parklane, Nigeria.
4 Department of Human Physiology, Faculty of Basic Medical Sciences, College of Health Sciences, Chukwuemeka Odumegwu Ojukwu University Uli, Nigeria.
ABSTRACT
Twenty (20) Wistar rats, each weighing between 180 and 200 grammes, were divided into five (5) groups of five rats for this study. The control group was designated as Group 1. Group 2 only received 2 millilitres of Lacasera. A laca-tomtom mixture of 1 ml and 1.6 ml was given to groups 3 and 4, respectively. For 30 days, the medication was administered orally. In a chamber saturated with chloroform, the rats were put to sleep. They were then dissected on a dissecting board, and the cerebellum was removed for histological analysis. The results showed that the laca-tomtom mixture at graded doses had a detrimental effect on the cerebellum, causing a decrease in motor function, motor coordination, and balance as demonstrated by the neurobehavioural test. The cerebellum’s histological examination revealed that the laca-tomtom mixture is detrimental to the cerebellum after the experimental groups’ purkinje cell size decreased.
Keywords: Laca-tomtom; neurobehavioural; cerebellum; histology
CITE AS: Nwodo N. Francis, Ogbo F. Ovie, Nwafor C. Charles and Ifedi I. Charles (2025). Dose-Dependent Impact of Laca-tomtom Mixture on Cerebellar Histomorphology in Wistar Rats. IAA Journal of Scientific Research 12(2):53-59. https://doi.org/10.59298/IAAJSR/2025/1225359.00