Protective Effects of Moringa oleifera Ethanolic Seed Extract on Nutmeg induced Kidney Tumorigenesis in Wistar Rats
1,3Ugwu, Valentine Ifebuchechukwu; 1,3,4 Ozor, Ignatius Ikemefuna; 2Uzoefuna, Chima Casmir; 1,3Nnachi, Ifenna Salvator and 5Ndu, Chidiebere Kingsley
1Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, State University of Medical and Applied sciences (SUMAS), Igbo-Eno, Enugu State, Nigeria.
2Department of Medical Biochemistry, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Medical and Applied Sciences (SUMAS), Igbo-Eno, Enugu State
3Department of Anatomy, Faculty of Basic Medical Sciences, College of Medicine, Enugu State University of Science and Technology (ESUT), Enugu, Nigeria.
4Department of Surgery, Faculty of Clinical Medicine, College of Medicine, Enugu State University of Science and Technology, Enugu, Nigeria.
5Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nsukka.
Corresponding author: Ozor II (ikemozor@yahoo.com, ignatius.ozor@esut.edu.ng; +2348033641955)
ABSTRACT
Recent studies suggest that chronic nutmeg exposure to be toxic to the kidney inducing aberrant cellular proliferation due to the Myristicin component which could promote tumorigenesis [1]. This necessitates the search for protective agents that can mitigate nutmeg-induced renal tumorigenesis. Sixteen (16) Wistar rats weighing 150g, was randomly selected into four groups. Group A received no treatment while Group B was administered 500 mg/kg of nutmeg seed extract. Group C received 500 mg/kg of nutmeg seed extract and 200mg/kg of moringa ethanolic seed extract. Group D was administered 500 mg/kg of nutmeg seed extract and 400mg/kg of moringa ethanolic seed extract. From the immunohistochemical analysis, the photomicrographs of groups B and C showed positive immunoreactivity to both CD117 and vimentin, while groups A and D had negative immunoreactivity to both CD117 and vimentin. The results from this study confirmed Moringa to be a potent natural protective agent for nutmeg induced kidney tumorigenesis which however, should be explored more for its possible application in clinical practices.
Keywords: Moringa oleifera, Ethanolic Seed Extract, Kidney Tumorigenesis and Wistar Rats
CITE AS: Ugwu, Valentine Ifebuchechukwu; Ozor, Ignatius Ikemefuna; Uzoefuna, Chima Casmir; Nnachi, Ifenna Salvator and Ndu, Chidiebere Kingsley (2025). Protective Effects of Moringa oleifera Ethanolic Seed Extract on Nutmeg induced Kidney Tumorigenesis in Wistar Rats. IAA Journal of Scientific Research 12(2):76-81. https://doi.org/10.59298/IAAJSR/2025/1227681.00